AOD 9604 (2mg)

Introduction

AOD-9604 (Anti-Obesity Drug 9604) is a modified fragment of human growth hormone (hGH), specifically comprising amino acids 176–191. It was developed to retain hGH’s metabolic fat-regulating effects without influencing growth or insulin-like growth factor-1 (IGF-1) activity. Research has focused on its potential to stimulate fat breakdown and prevent fat accumulation in preclinical models.

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Stability and Bioavailability

AOD-9604 demonstrates strong stability in research models and maintains activity at low concentrations. Unlike full-length hGH, it does not stimulate growth pathways or cell proliferation, which makes it suitable for research focused exclusively on fat metabolism. Its resistance to degradation and targeted activity on adipose tissue metabolism has made it a consistent subject of laboratory study.

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Research Applications

Metabolic Regulation

Preclinical studies indicate AOD-9604 may promote lipolysis (breakdown of fat) and inhibit lipogenesis (formation of new fat). These dual actions suggest a potential role in regulating body composition and energy balance in animal models.

Obesity and Weight Management Research

Animal research has explored AOD-9604’s effects on reducing fat accumulation in high-fat diet models. Findings have shown potential in reducing adiposity without altering lean muscle mass, distinguishing it from other growth hormone derivatives.

Safety Profile in Research Settings

Unlike native hGH, AOD-9604 has not demonstrated growth-promoting effects in tested models. This makes it a valuable peptide for exploring metabolic research questions without the confounding influence of growth factor pathways.

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Summary

AOD-9604 is a synthetic fragment of human growth hormone studied primarily for its metabolic effects. With evidence suggesting it can influence fat breakdown and limit fat storage in animal models, it provides a targeted approach to research on adiposity and energy balance. Its stability and absence of growth-promoting effects highlight its distinct role in scientific investigations.

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References

1. Heffernan M et al., The C-terminal fragment of human growth hormone: metabolic and lipolytic activity in animal models, Obesity Research (2001). PubMed

2. Ng FM et al., GH fragment AOD9604 reduces adiposity in obese mice, International Journal of Obesity (2000). PubMed

 

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.