MT-1 (15mg)
$50.00
MT-1, also known as Afamelanotide or Melanotan I, is a synthetic analog of the naturally occurring α-Melanocyte Stimulating Hormone (α-MSH). It is primarily studied for its role in pigmentation, photoprotection, and melanocortin receptor activity. Research applications often include studies of cellular photobiology, skin barrier response, and melanin synthesis regulation.
In stock
Additional info
Introduction
Melanotan I (MT-1) is a synthetic peptide analog of α-Melanocyte Stimulating Hormone (α-MSH), designed to mimic its binding affinity for the melanocortin-1 receptor (MC1R). Through this receptor pathway, MT-1 modulates melanin production and provides a valuable research model for studying pigmentation and UV-induced oxidative responses. In research, MT-1 is utilized to explore melanogenesis, DNA repair mechanisms following UV exposure, and the broader role of melanocortin receptors in inflammation and immune modulation.
Stability and Bioavailability
MT-1 demonstrates strong structural stability, largely due to its cyclic configuration which enhances resistance to enzymatic degradation. When stored appropriately under laboratory conditions, it maintains high purity and receptor-binding integrity, allowing reproducible results in melanocortin receptor activation assays. Its enhanced stability compared to α-MSH makes it particularly suitable for long-term in-vitro studies.
Research Applications
Melanocortin Receptor Activation
MT-1 acts as a potent agonist of the MC1R receptor, which regulates pigmentation and photoprotective responses in skin cell cultures. Studies utilize MT-1 to assess receptor signaling, cyclic AMP activity, and melanin biosynthesis in melanocytes.
Photoprotection and DNA Repair Studies
By increasing melanin synthesis, MT-1 contributes to enhanced UV resistance in research models. It has been used to explore mechanisms of oxidative DNA damage repair and skin cell defense following ultraviolet exposure.
Inflammation and Immune Response Regulation
The melanocortin pathway, activated by MT-1, is linked to anti-inflammatory processes. Laboratory research continues to explore its role in regulating cytokine expression and immune cell signaling, contributing to the understanding of melanocortin receptor biology.
Cellular Stress and Oxidative Response
MT-1 provides a model for analyzing intracellular oxidative stress and antioxidant responses in epithelial and dermal cells, contributing to studies on skin barrier health and environmental stress adaptation.
Summary
MT-1 (Afamelanotide) is a stable and selective MC1R agonist peptide used in research exploring melanogenesis, photoprotection, and cellular response to UV stress. Its high receptor affinity and structural resilience make it a cornerstone compound for studying the complex biology of the melanocortin system.
References
- Dorr RT et al., Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers, Arch Dermatol. (2004). PubMed
-
Böhm M., [Melanocortin peptides : Fundamentals, translational research, clinical dermatology, and future perspectives], Hautarzt. (2020). PubMed
-
Thapa K et al., Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver, Elife. (2023). PubMed
-
Langendonk JG et al., Afamelanotide for Erythropoietic Protoporphyria, N Engl J Med. (2016). PubMed
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
Storage Instructions
All peptides are manufactured using lyophilization (freeze-drying), a process that protects product integrity during shipping and storage. This ensures that peptides remain stable for 3–4 months while in their lyophilized form.
Once reconstituted (mixed with bacteriostatic water), peptides should be stored in the refrigerator and will remain stable for up to 30 days.
Lyophilized peptides (unmixed powder) can be kept at room temperature for short-term storage but should ideally be refrigerated under 4°C (39°F) to maintain stability. For long-term preservation (several months to years), peptides should be stored in a freezer at -20°C to -80°C (-4°F to -112°F).
Proper storage helps maintain purity and quality, ensuring your peptides are reliable for research use.
More Peptides:
-
$50.00
Select options This product has multiple variants. The options may be chosen on the product page -
$15.00
-
$220.00
